“Pharmacological Evaluation of Anti-arthiritic activity of Euphorbia hirta Plant Extract on Rats”.

Euphorbia hirta is of the family Euphorbiaceae, owning various pharmacological properties like anti-inflammatory activity. Rheumatoid Arthritis (RA) is a chronic-autoimmune systemic diseasethat can be characterized by cartilage degradation, synovial hyperplasia, inflammation, and joint damage. Objective of the study is to assess the anti-arthritic activity of methanolic extract of Euphorbia hirta. Freund’s complete adjuvant induced arthritic Model was followed for the evaluation. 0.1 mL of the FCA by intraplanar injection was used to induce arthritis in Wistar rats. Methanolic extract (100 and 200 mg/kg) of Euphorbia hirta were given to Wistar rats. Euphorbia hirta extract showed significant anti-arthritic activity in a dose-dependent manner. However, Euphorbia hirta extract (200mg/kg) showed potential anti-arthritic activity. From the study, it can be concluded that Euphorbia hirta possesses marked anti-arthriticactivity. [ABSTRACT FROM AUTHOR]