To Determine Occurrence of Contralateral Breast Cancer in Patients of Carcinoma Breast.

Background: Breast cancer (BC) is one of the most prevalent types of cancer among women. Contralateral breast carcinoma is the most prevalent second malignancy in breast cancer patients. There are two types of bilateral breast carcinomas: synchronous, in which both tumors arise simultaneously, and metachronous, in which they occur at different periods. When a patient is diagnosed with breast cancer, the contralateral breast should be thoroughly examined for a synchronous tumor. Screening for hidden contralateral breast cancer is crucial for the early detection of malignancy Method: The data will be collected in prospective way. The study subjects will be involved who pre-diagnosis of unilateral breast cancer and attending surgery OPD and admitted in surgery ward. After physical examination and assessment of the patients Data will be collected pre designed proforma. They have to undergo routine blood investigation, X-ray, Mammogram and MRI for diagnosis of contralateral breast carcinoma. Results: In our study of 101 married female cases, the incidence of contralateral breast carcinoma was 3.96%. Most women in both contralateral breast carcinoma (CBC) and primary breast carcinoma groups experienced menarche at ages 13-14. The majority were diagnosed at stage 2, with CBC showing highest incidence among ages 41-50 and primary breast carcinoma among ages 51-60, indicating earlier presentation of CBC. Postmenopausal CBC patients were aged 40-50 at menopause, suggesting varying protection compared to primary breast carcinoma. No patients had a positive family history of breast carcinoma. Symptoms commonly included breast lump and mastalgia in CBC. Parity and breastfeeding duration did not significantly protect against CBC. Tumor characteristics revealed multifocality in CBC with equal distribution across breast quadrants, while primary breast carcinoma predominantly affected the upper outer quadrant. CBC tumors varied in size and showed no chest wall involvement but higher rates of skin and lymph node involvement compared to primary breast carcinoma. IDC was uniformly predominant in both CBC and primary breast carcinoma cases. Conclusions: In conclusion, our study underscores several key insights into contralateral breast carcinoma (CBC) among married females. CBC tends to manifest earlier than primary breast carcinoma, typically between ages 41-50, contrasting with the later onset of primary breast carcinoma in the 51-60 age range. Postmenopausal CBC cases aged 40-50 at menopause suggest varied protective effects compared to primary breast carcinoma, emphasizing the need for tailored screening strategies. The absence of positive family history and common symptoms such as breast lump and mastalgia highlight the sporadic nature of CBC cases. All CBC cases were of invasive ductal carcinoma (IDC) type, reinforcing IDC as the predominant histopathological subtype in both primary and contralateral breast carcinomas. Hormone receptorpositive subtype (ER+ve, PR+ve, Her2nu-ve) was prevalent in both groups. Early detection through comprehensive clinical, radiological, and histopathological assessments remains critical for improving outcomes and underscores the importance of rigorous breast examination and screening protocols. [ABSTRACT FROM AUTHOR]