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Porcine epidemic diarrhea virus: A review of detection, inhibition of host gene expression and evasion of host innate immune.
Porcine epidemic diarrhea virus: A review of detection, inhibition of host gene expression and evasion of host innate immune.
- Source :
-
Microbial Pathogenesis . Oct2024, Vol. 195, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
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Abstract
- As one of the most important swine enteropathogenic coronavirus, porcine epidemic diarrhea virus (PEDV) is the causative agent of an acute and devastating enteric disease that causes lethal watery diarrhea in suckling piglets. Recent progress in studying PEDV has revealed many intriguing findings on its prevalence and genetic evolution, rapid diagnosis, suppression of host gene expression, and suppression of the host innate immune system. Due to the continuous mutation of the PEDV genome, viral evasions from innate immune defenses and mixed infection with other coronaviruses, the spread of the virus is becoming wider and faster, making it even more necessary to prevent the infections caused by wild-type PEDV variants. It has also been reported that PEDV nsp1 is an essential virulence determinant and is critical for inhibiting host gene expression by structural and biochemical analyses. The inhibition of host protein synthesis employed by PEDV nsp1 may contribute to the regulation of host cell proliferation and immune evasion-related biological functions. In this review, we critically evaluate the recent studies on these aspects of PEDV and assess prospects in understanding the function of PEDV proteins in regulating host innate immune response and viral virulence. • PEDV is an important pathogenic microorganism that has a devastating impact on the swine industry. • The development of rapid diagnostic methods is important to curb the spread of PEDV and reduce economic losses. • PEDV nsp1 is an essential virulence determinant and is critical for inhibiting host gene expression. • PEDV M protein may contribute to evade the host innnate immune response and promote its replication. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08824010
- Volume :
- 195
- Database :
- Academic Search Index
- Journal :
- Microbial Pathogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 179633651
- Full Text :
- https://doi.org/10.1016/j.micpath.2024.106873