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Efficacy and Safety of Liraglutide in Patients With an Ileal Pouch-Anal Anastomosis and Chronic High Bowel Frequency: A Placebo-Controlled, Crossover, Proof-of-Concept Study.
- Source :
-
American Journal of Gastroenterology (Lippincott Williams & Wilkins) . Sep2024, Vol. 119 Issue 9, p1935-1938. 4p. - Publication Year :
- 2024
-
Abstract
- INTRODUCTION: After colectomy with ileoanal pouch anastomosis (IPAA), many patients develop high bowel frequency (BF) refractory to antimotility agents, despite normal IPAA morphology. Low circulating levels of glucagon-like protein-1 (GLP-1), a modulator of gastroduodenal motility, have been reported after colectomy. METHODS: Double-blind crossover study of 8 IPAA patients with refractory high BF treated with daily administration of the GLP-1 receptor agonist liraglutide or placebo. RESULTS: Liraglutide, but not placebo, reduced daily BF by more than 35% (P < 0.03). DISCUSSION: Larger randomized controlled studies are warranted to delineate the treatment potential of GLP-1 receptor agonists in IPAA patients suffering from noninflammatory high BF. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00029270
- Volume :
- 119
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- American Journal of Gastroenterology (Lippincott Williams & Wilkins)
- Publication Type :
- Academic Journal
- Accession number :
- 179651978
- Full Text :
- https://doi.org/10.14309/ajg.0000000000002801