Membrane remodeling via ubiquitin-mediated pathways.

The dynamic process of membrane shaping and remodeling plays a vital role in cellular functions, with proteins and cellular membranes interacting intricately to adapt to various cellular needs and environmental cues. Ubiquitination—a posttranslational modification—was shown to be essential in regulating membrane structure and shape. It influences virtually all pathways relying on cellular membranes, such as endocytosis and autophagy by directing protein degradation, sorting, and oligomerization. Ubiquitin is mostly known as a protein modifier; however, it was reported that ubiquitin and ubiquitin-like proteins can associate directly with lipids, affecting membrane curvature and dynamics. In this review, we summarize some of the current knowledge on ubiquitin-mediated membrane remodeling in the context of endocytosis, autophagy, and ER-phagy. [Display omitted] In their review, Jacomin and Dikic discuss the role of ubiquitination in regulating membrane structure and its impact on pathways such as endocytosis and autophagy. Besides protein modification, ubiquitin also interacts with lipids, directly influencing membrane dynamics. The review covers ubiquitin-mediated membrane remodeling in endocytosis, autophagy, and ER-phagy. [ABSTRACT FROM AUTHOR]