接种三剂新冠病毒灭活疫苗后抗新冠病毒抗体动态变化研究.

Objective To explore the dynamic changes of anti-coronavirus antibodies in medical staff of intensive care unit after three doses of novel coronavirus inactivated vaccine, and to dynamically evaluate their immune status. Methods A total of 30 medical staff in intensive care unit who received three doses of inactivated SARS-CoV-2 vaccine in this hospital from November 2020 to November 2021 were selected as the research objects. Venous blood samples were collected at 0, 1, 3, 6 and 12 months after inoculation of novel coronavirus vaccine to detect the titer of anti-novel, coronavirus antibody immunoglobulin G, lymphocyte subsets and cytokines, and the changes were analyzed. Results Anti-coronavirus antibodies were positive in 30 medical staff one month after injection of three doses of inactivated coronavirus vaccine, and the titer increased significantly in the first month, with statistically significant difference (P＜0. 05). In the first month, the anti-neo-coronavirus antibody reached a peak and then gradually decreased. In the 12th month, the anti-neo-coronavirus antibody was still higher than that in the 0 th month, and the difference was statistically significant (P＜0. 05). There was no significant difference in lymphocyte subsets at different time points (P＞0. 05). After inoculation with the novel coronavirus inactivated vaccine, interleukin-2 (IL-2), IL-10, interferon-γ, and tumor necrosis factor-α all showed inverted U-shaped changes, IL-6 showed U-shaped changes, and IL-4 showed fluctuating changes. Conclusion The three-dose inactivated vaccine can produce a higher level of antibody and maintain a high titer for at least six months. [ABSTRACT FROM AUTHOR]