The role of gut microbiota and metabolites in cancer chemotherapy.

[Display omitted] • We elaborate on the role of gut microbiota and microbial metabolites in the efficacy and adverse effects of chemotherapeutics. • We further summarize the clinical potential of various ways to harness gut microbiota for cancer chemotherapy. • The potential of gut microbiota severing as predictive markers for chemotherapy efficacy is discussed. • Finally, we discuss current limitations and suggest potential approaches to facilitate utilization of gut microbiota in chemotherapy. The microbiota inhabits the epithelial surfaces of hosts, which influences physiological functions from helping digest food and acquiring nutrition to regulate metabolism and shaping host immunity. With the deep insight into the microbiota, an increasing amount of research reveals that it is also involved in the initiation and progression of cancer. Intriguingly, gut microbiota can mediate the biotransformation of drugs, thereby altering their bioavailability, bioactivity, or toxicity. The review aims to elaborate on the role of gut microbiota and microbial metabolites in the efficacy and adverse effects of chemotherapeutics. Furthermore, we discuss the clinical potential of various ways to harness gut microbiota for cancer chemotherapy. Recent evidence shows that gut microbiota modulates the efficacy and toxicity of chemotherapy agents, leading to diverse host responses to chemotherapy. Thereinto, targeting the microbiota to improve efficacy and diminish the toxicity of chemotherapeutic drugs may be a promising strategy in tumor treatment. [ABSTRACT FROM AUTHOR]