سنتز نانونیوزوم‌های حاوی عصاره گیاه درمنه بیابانی (L. Artemisia deserti): شناسایی ترکیبات گیاهی، اثرات ضدمیکروبی و سمیت سلولی نانونیوزوم‌های سنتز شده.

Introduction Nanoniosomes are multi-layered vesicles that are used as one of the new targeted drug delivery systems today. In this study, the extract of the Artemisia deserti L. was encapsulated in nanonisomes and its antimicrobial and cytotoxic effects were studied. Materials and Methods In this experimental study, nanonisomes containing the extract of Artemisia deserti were synthesized and their appearance and structural characteristics were investigated. After confirming the structure, its antimicrobial and anti-biofilm effects on Klebsiella pneumoniae pathogenic strains were investigated. Finally, in order to check the biocompatibility, the colorimetric method of nanonisomes cytotoxicity was used on HFF normal fibroblast cell line. Results The results of niosomes synthesis showed that the synthesized nanoniosomes have a spherical structure and have a size of 125.4 ± 29.3 nm. In addition, FTIR results confirmed the synthesis of niosomes. The results of the antimicrobial effects showed that the nanoniosomes containing the medicinal extract have more significant antimicrobial and anti-biofilm effects than the extract alone, so that the minimum inhibitory concentration (MIC) of the niosomes was reduced between 2 and 4 times. Also, the cytotoxicity results showed that the synthesized niosomes do not have significant cytotoxicity effects. Conclusion In general, the results of this study showed that nanonisomes can act as a suitable drug delivery system for medicinal plant extract to increase the amount of antimicrobial and anti-biofilm effects. Therefore, with further studies, this system can be used as an optimal drug delivery system for medicinal purposes. [ABSTRACT FROM AUTHOR]