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Nickel N‐heterocyclic carbene complexes based on xanthines: Synthesis and antifungal activity on Candida sp.

Authors :
Francescato, Giulia
Silva, Sofia M. da
Leitão, Maria Inês P. S.
Gaspar‐Cordeiro, Ana
Giannopoulos, Nikolaos
Gomes, Clara S. B.
Pimentel, Catarina
Petronilho, Ana
Source :
Applied Organometallic Chemistry. Oct2024, Vol. 38 Issue 10, p1-8. 8p.
Publication Year :
2024

Abstract

Invasive fungal diseases affect more than two million people worldwide. The increasing incidence of invasive fungal infections is the result of many factors, including an increase in the resistance to current drugs. As such, there is an urgent need to obtain new drugs that are efficient, selective, and able to overcome existing resistance mechanisms. Candida yeasts are responsible for more than 70% of all nosocomial invasive fungal diseases. In this work, we describe the synthesis of nickel (II)(NHC) complexes based on xanthines, by direct metalation of xanthinium salts with nickelocene NiCp2to yield [NiCpI(NHC)] complexes. For methyl caffeine, a biscarbene complex [NiCp(NHC)2]+is also formed, resulting from carbene dissociation from the corresponding monocarbene. [NiCpI(NHC)] complexes are active as antifungals for Candida yeasts and show toxicity for human cells (HeLa) that is dependent on the substitution of N7 of the xanthine moiety. The biscarbene complex 5[NiCp(NHC)2]+is highly selective for Candida glabrata and shows very low toxicity for human cells, being a promising candidate for selective treatment of C. glabrata infections. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02682605
Volume :
38
Issue :
10
Database :
Academic Search Index
Journal :
Applied Organometallic Chemistry
Publication Type :
Academic Journal
Accession number :
179879002
Full Text :
https://doi.org/10.1002/aoc.6687