Voltammetric Determination of Itopride Hydrochloride in a Solid Dosage Form.

A voltammetric method for determining itopride hydrochloride (ITP) based on titration of the analyte with a solution of photogenerated iodine obtained by irradiation of an auxiliary solution containing potassium iodide and a mixture of sensitizers (nsodium eosinate:nuranine = 1:1) at pH 5.68 was developed. Stabilization of the current in the amperometric unit circuit indicated the reaction of the titrant with ITP was complete and provided control of the ITP content in the preparation by the change in the current strength because the iodine content in the solution was controlled by a voltammetric method. Further irradiation of the solution and measurement of the generation time required to replenish the lost titrant also allowed regulation of the ITP content in the preparation. The dependence of the analytical signal on the ITP concentration was linear in the range 8.0 – 40.0 mg. The calculated limits of detection (LD) and quantification (LQ) were 33.0 and 11.0 mg by varying the current and generation time, respectively. The developed method met requirements given in the manual on validation of bioanalytical methods, was easy to use, and did not require expensive equipment and reagents. Therefore, it could be recommended for routine control of drug quality parameters in any analytical laboratory. [ABSTRACT FROM AUTHOR]