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Recurrent MTOR Mutations in Renal Cell Carcinoma With Fibromyomatous Stroma: A Report of 2 Tumors.
- Source :
-
International Journal of Surgical Pathology . Oct2024, Vol. 32 Issue 7, p1409-1414. 6p. - Publication Year :
- 2024
-
Abstract
- Renal cell carcinoma with fibromyomatous stroma, recognized as a provisional entity in the current 2022 World Health Organization classification of renal neoplasms, is rare. Recent evidence suggests recurrent alterations in the mTOR pathway, supporting its recognition as a distinct entity. Herein, we report 2 renal cell carcinomas with fibromyomatous stroma with MTOR mutations occurring in 62- and 72-year-old women and review the literature to support its recognition as a distinct entity, focusing on the characteristic morphology, immunohistochemical staining patterns as well as genetic alterations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10668969
- Volume :
- 32
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- International Journal of Surgical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 179974234
- Full Text :
- https://doi.org/10.1177/10668969241228295