不同肥胖指标与非酒精性脂肪肝的关系.

Objective To investigate the relationship between nonalcoholic fatty liver disease (NAFLD) and various obesity indicators, as well as to investigate their predictive value for NAFLD. Methods A total of 3 102 participants who underwent health examinations from April to August 2023 at the Xinshi Street Community Health Service Center in Baiyun District, Guangzhou, and the Junan Community Health Service Center in Shunde District, Foshan, were selected and divided into NAFLD and non-NAFLD groups. Logistic regression analysis was employed to examine the relationship between body mass index (BMI), weight-adjusted waist index (WWI), waist-height ratio (WHtR), waist circumference (WC), and NAFLD. Receiver operating characteristic (ROC) curves were used to evaluate the predictive ability of individual and combined obesity indicators for NAFLD. Results The prevalence of NAFLD in this study was 34.9%. All obesity indicators in the NAFLD group were significantly higher than those in the non-NAFLD group (all P<0.001). Multivariate logistic regression results indicated that all obesity indicators were associated with the risk of NAFLD (all P<0.05). ROC curve analysis showed that each obesity indicator could predict the risk of NAFLD (AUC>0.5 for all). Among females, BMI exhibited the best predictive power (P<0.05), while the AUC values for BMI (overall population) and WC (males) were slightly higher than those for the other three indicators, though without statistical significance (P>0.05). Compared to traditional obesity indicators, WWI did not demonstrate superior predictive power (P<0.05). In all populations, combined indicators showed better predictive efficacy than single obesity indicators (P<0.05), and the AUC value for the combined indicators of BMI and WC was slightly higher in all three populations but did not show significant statistical meaning (P>0.05). Conclusion BMI, WC, WHtR, and WWI are associated with the prevalence of NAFLD. The best predictive indicator for females is BMI. The new indicator WWI do not show better predictive ability compared to traditional obesity indicators across the three populations. Combined indicators demonstrate better predictive efficacy than single indicators. [ABSTRACT FROM AUTHOR]