Hypervalent Iodine‐Mediated C3‐Trifluoropropionyloxylation of N‐Substituted Indoles.

A metal‐free hypervalent iodine‐mediated C3‐trifluoropropionyloxylation of N‐substituted indoles was developed. (Bis‐trifluoropropanoate)iodobenzene was used as both the oxidant and fluorine source. The reaction was sensitive to the N‐protecting groups of the indoles. N‐acylated indoles provided 3‐trifluoropropionyloxylated indoles, while 3‐trifluoropropionyloxylated oxindoles were generated from indoles bearing N‐alkyl groups. [ABSTRACT FROM AUTHOR]