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Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39.

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39.

Authors :
Devantier, Kira
Kjær, Viktoria M. S.
Griffin, Stephen
Kragelund, Birthe B.
Rosenkilde, Mette M.
Source :
British Journal of Pharmacology. Nov2024, Vol. 181 Issue 22, p4450-4490. 41p.
Publication Year :
2024

Abstract

Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging. These challenges relate in varying proportions to a lack of reliable full‐length 3D‐structures, difficulties in functionally characterising individual viroporins, and absence of verifiable direct binding between inhibitor and viroporin. This review offers perspectives to help overcome these challenges. We provide a comprehensive overview of the viroporin family, including their structural and functional features, highlighting the moldability of their energy landscapes and actions. To advance the field, we suggest a list of best practices to aspire towards unambiguous viroporin identification and characterisation, along with considerations of potential pitfalls. Finally, we present current and future scenarios of, and prospects for, viroporin targeting drugs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00071188
Volume :
181
Issue :
22
Database :
Academic Search Index
Journal :
British Journal of Pharmacology
Publication Type :
Academic Journal
Accession number :
180136870
Full Text :
https://doi.org/10.1111/bph.17317