化积散结散联合温针灸治疗类风湿关节炎合并 肺间质病变的疗效及对类风湿因子, 免疫应答 和抗 CCP 抗体, CCL19 的影响.

OBJECTIVE: To probe into the efficacy of Huaji Sanjie powder combined with warm-needling moxibustion in the treatment of rheumatoid arthritis complicated with interstitial lung disease and its effects on rheumatoid factor, immune response, anti-cyclic citrullinated peptide (CCP ) antibody and chemokine ligand (CCL19). METHODS: A total of 98 patients with rheumatoid arthritis complicated with interstitial lung disease admitted into Baoding Hospital of Guang' anmen Hospital of Chinese Academy of Chinese Medical Sciences and the 82nd Group Military Hospital of the Chinese People's Liberation Army from Apr. 2020 to Apr. 2023 were extracted to be divided into two groups via the random number table method. Forty-nine patients in Western medicine group was given conventional Western medicine, while the 49 patients in the combined group was given Huaji Sanjie powder combined with warm-needling moxibustion based on the Western medicine group. After 3 months of treatment, the clinical efficacy were compared between two groups, traditional Chinese medicine (TCM) symptom scores, rheumatoid arthritis disease activity scores (DAS-28) and lung high-resolution CT (HRCT) scores before and after treatment were observed, the rheumatoid factor (RF), anti-CCP antibody, CCL19, interleukin 4 (IL-4), tumor necrosis factor α (TNF-α) levels and Th1/Th2 were detected. RESULTS: The total effective rate of the combined group was 97. 96% (48/49), higher than 81. 63% (40/49) of the Western medicine group, with statistically significant difference (P< 0. 05). After treatment, the TCM symptom score, DAS-28 and HRCT scores in combined group were lower than those in Western medicine group, with statistically significant differences (P<0. 05). After treatment, the Th1/Th2 and TNF-α levels were lower, the IL-4 level was higher, the RF, anti-CCP antibody and CCL19 levels were lower in the combined group than those in the Western medicine group, with statistically significant differences (P < 0. 05). CONCLUSIONS: Huaji Sanjie powder combined with warm-needling moxibustion in the treatment of rheumatoid arthritis complicated with interstitial lung disease can regulate immune response, inhibit inflammation, reduce rheumatoid factors, anti-CCP antibody and CCL19 levels, improve clinical symptoms and TCM syndrome scores, and promote clinical efficacy. [ABSTRACT FROM AUTHOR]