生物医学领域碳纳米材料 10 年研究前沿与热点.

BACKGROUND: Research on carbon nanomaterials in the biomedical field is booming, and related scientific research results are increasing year by year. However, visualization analysis of the annual number of publications, the research status of countries, institutions, authors, and research hotspots and trends in this field is relatively scarce. OBJECTIVE: To present the research status of carbon nanomaterials in biomedical field, reveal the main research subjects, explore the research hotspots and development trends, and provide a reference for the future development of this field. METHODS: The core data set of Web of Science was used as the literature source to search the relevant researches on carbon nanomaterials in the biomedical field from 2012 to 2023. The knowledge map was generated by using Citespace software with countries, institutions, authors, keywords, and co-citations as nodes and for visualization analysis. RESULTS AND CONCLUSION: (1) A total of 2 932 papers were included in this study. In the medical field, carbon nanomaterials had a large number of papers and a fast growth rate. The United States has a large number of papers; China is an emerging force in this field, although the number of papers is the largest, but the level of research and influence need to be improved. The Chinese Academy of Sciences is the largest cooperative network institution, which mainly targets domestic institutions and lacks cooperation with well-known foreign institutions. (2) Keyword analysis displays that the green synthesis method and application of displaying carbon points have been the focus of research, followed by the new method of combining carbon nanomaterials with cancer phototherapy and immunotherapy, the key direction of future research. (3) The dynamic development trend of co-citations suggests that tissue engineering is a hot research topic of carbon nanomaterials in the field of biomedicine, mainly including the research of carbon nanomaterials for the repair and regeneration of heart and nerve tissue and as a bio-ink additive for 3D and 4D bioprinting. (4) In the future, with the development of the biomedical field in the direction of precision and treatment, researchers should speed up the creation of carbon-based systems formed by the combination of scientific and effective carbon nanomaterials with science and technology, new polymers or organic molecules, and new therapeutic methods, so as to give full play to the maximum effect of carbon nanomaterials. [ABSTRACT FROM AUTHOR]