Association between gallstones and cardiovascular diseases and the mediating effect of glomerular filtration rate in the minority population, Guizhou Province.

Objective To explore the association between gallstones and CVD among ethnic minority populations in Guizhou Province, as well as the mediating effect of glomerular filtration rate (GFR) in this association, in order to provide reference suggestions for reducing the burden of CVD. Methods Based on the database of Cohort Study of Native Natural Population in Ethnic Minority Gathering Areas in Southwest China, stratified and multi-stage cluster sampling was used to conduct a baseline survey of ethnic minorities aged 30 - 79 years in Qiandongnan and Qiannan Prefectures of Guizhou Province from 2018 to 2019. Multivariate logistic regression was used to analyze the association between gallstones and CVD, and the mediating effect model was used to evaluate the mediating effect of glomerular filtration rate in the association. Results The detection rate of CVD in Guizhou minority population was 3.16%, among which the detection rates of Dong, Miao and Buyi were 3.27%, 3.07% and 3.12%, respectively. The total detection rate of gallstones was 9.03%. Logistic regression analysis showed that after adjusting for all the variables (model 3), the detection rates of CVD in the total population [OR(95%CI): 1.633(1.269-2.102)], the Dong [OR(95%CI): 1.567(1.077-2.280)], and Miao [OR(95%CI): 1.679(1.055-2.673)], gallstones were positively associated with CVD. No association between gallstones and CVD was found in the Buyi population. Subgroup analysis showed that Dong patients with gallstones < 60 years old were positively correlated with CVD [OR(95%CI): 1.825(1.022-3.258)], gallstone patients without hyperlipidemia [OR(95%CI): 2.151(1.352-3.422)], gallstone patients without hypertension [OR(95%CI): 1.612(1.013-2.565)] were positively correlated with CVD. Miao ≥ 60 years old [OR(95%CI): 1.878(1.038-3.397)], male [OR(95%CI): 1.546(1.212-5.586)], BMI ≥ 24 [OR(95%CI): 1.972(1.160-3.354)], gallstone patients with hypertension [OR(95%CI): 2.264(1.297 - 5.429)] were positively correlated with CVD. Mediation analysis revealed that the glomerular filtration rate accounted for 16.96%, 12.08%, 17.43%, and 14.52% of the mediating effect between gallstones and CVD in the total population, Dong, Miao, and Buyi people, respectively. Conclusion Gallstones are positively correlated with CVD in the Dong and Miao populations in Guizhou Province, especially in the overweight and hypertension population of the Miao nationality. There is no association between gallstones and CVD in the Buyi population. Glomerular filtration rate has a partial mediating effect between gallstones and CVD. [ABSTRACT FROM AUTHOR]