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Dosing overground robotic gait training after spinal cord injury: a randomized clinical trial protocol.

Authors :
Suhalka, Alexandria
da Silva Areas, Fernando Zanela
Meza, Faith
Ochoa, Christa
Driver, Simon
Sikka, Seema
Hamilton, Rita
Goh, Hui-Ting
Callender, Librada
Bennett, Monica
Shih, Hui-Ting
Swank, Chad
Source :
Trials. 10/18/2024, Vol. 25 Issue 1, p1-10. 10p.
Publication Year :
2024

Abstract

Background: Robotic exoskeletons have changed rehabilitation care available to people after spinal cord injury (SCI). Yet, the current evidence base is insufficient to identify the optimal dose and neurophysiological mechanism of robotic exoskeleton gait training (RGT) as an effective rehabilitation approach. This study will (1) examine whether the frequency of RGT after motor incomplete SCI impacts function and health outcomes, (2) analyze the neuroplastic effects of RGT dose, and (3) evaluate the safety, tolerability, and feasibility of delivering RGT. Methods: We will enroll 144 participants with motor incomplete SCI admitted to inpatient rehabilitation within 6 months of SCI. Participants will be randomized based on injury severity and level into one of 3 RGT frequency groups (high, moderate, low) or none/usual care only. Participants will complete 24 RGT sessions and be assessed at admission and discharge to inpatient rehabilitation, post-RGT intervention, 1-month post-RGT, and 9-month post-SCI. Outcomes include Walking Index for Spinal Cord Injury-II, health outcomes (gait speed, Spinal Cord Independence Measure, pain, fatigue, spasticity, general health, quality of life, physical activity), and motor evoked potential amplitudes obtained using transcranial magnetic stimulation. Discussion: Successful completion of this study will provide an evidence-based intervention, specifically tailored to meet the unique needs of people with SCI, which supports walking recovery; maximizing health, function, and ultimately participation. The intervention will further support widespread clinical implementation of exoskeleton use during acute rehabilitation. Trial registration: ClinicalTrials.gov NCT05218447. Registered on June 23, 2022. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17456215
Volume :
25
Issue :
1
Database :
Academic Search Index
Journal :
Trials
Publication Type :
Academic Journal
Accession number :
180369557
Full Text :
https://doi.org/10.1186/s13063-024-08503-0