质子泵抑制剂预防骨科 NSAIDs相关性胃黏膜损伤的 合理性评价.

Objective To investigate the use of proton pump inhibitors (PPIs) for preventing non-steroidal anti-inflammatory drug (NSAID) related gastric mucosal injury in orthopedic patients and to evaluate its rationality, providing a reference for the proper use of PPIs. Methods A retrospective survey was conducted, collecting data from January 1,2022, to December 31,2022, on orthopedic patients who used PPIs to prevent NSAID-related gastric mucosal injury. The study assessed whether patients had indications for prophylactic use of PPIs and then evaluated the appropriateness of drug selection, timing of administration, dosage, and duration of treatment in cases with indications. Results Out of 307 patients, 62(20.20%) did not have indications for prophylactic use of PPIs. Among the 245 instances where there were indications, 83 instances (33.88%) involved inappropriate medication use, primarily due to unsuitable drug selection, inappropriate timing of administration, inappropriate frequency of administration, and excessively long treatment duration. Conclusion The inappropriate use of PPIs to prevent NSAID-related gastric mucosal injury in the orthopedics department is notable. Physicians should strictly control the indications for medication use, and pharmacists should enhance prescription review to jointly promote the rational use of drugs. [ABSTRACT FROM AUTHOR]