IL36RN mutations in Chinese patients with acute generalized exanthematous pustulosis.

The article discusses IL36RN mutations in Chinese patients with acute generalized exanthematous pustulosis (AGEP), a severe skin disease characterized by sterile pustules on an erythematous background. IL36RN mutations have been linked to AGEP development, with a specific mutation, c.115+6T>C, identified in Chinese patients. The study suggests that IL36RN mutations exacerbate IL36 signaling, leading to immune cell recruitment and pustule formation in AGEP, but not all AGEP patients carry IL36RN mutations, indicating other potential causes. Further research is needed to confirm these findings and explore other factors contributing to AGEP. [Extracted from the article]