Impact of CRISPR in cancer drug discovery.

The article discusses the transformative impact of CRISPR-Cas9, a precise gene-editing tool, on cancer drug discovery, emphasizing its capability for large-scale genetic screenings to identify essential genes and genetic interactions. Topics include the Cancer Dependency Map for therapeutic targets, exploration of synthetic lethality, and CRISPR applications in organoids and in vivo studies to enhance tumor behavior understanding and therapeutic responses.