Humanized immune system mouse model and its application in tumor immunotherapy.

Effectiveness of tumor immunotherapy is largely evaluated based on mouse models. Due to species differences, traditional mouse models cannot mirror condition of immune response in human body, resulting in vast majority of mouse-based achievements are not applicable to humans. In recent years, with emergence of immunodeficient mice and its improvement, humanized immune system mouse models based on immunodeficient mice are expected to help us overcome this barrier. We highlight the latest advances and barriers in generation of immunodeficient mice and humanized mouse models, as well as application of humanized mouse models on tumor immune, with aim of providing a guide for their application to tumor immunotherapy studies with potential for clinical translation. [ABSTRACT FROM AUTHOR]