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Associations of Amino Acids with the Risk of Prediabetes: A Case-Control Study from Kazakhstan.

Authors :
Nurtazina, Alma
Voitsekhovskiy, Ivan
Kanapiyanov, Bakyt
Toishimanov, Maxat
Dautov, Daulet
Karibayev, Kairat
Smail, Yerbol
Kozhakhmetova, Dana
Dyussupov, Altay
Source :
Journal of Personalized Medicine. Oct2024, Vol. 14 Issue 10, p1067. 16p.
Publication Year :
2024

Abstract

Background: The high global prevalence of prediabetes requires its early identification. Amino acids (AAs) have emerged as potential predictors of prediabetes. This study investigates the association between amino acids and prediabetes in the Kazakh population. Materials and Methods: In this case-control study, serum AAs levels were measured using the Trace GC 1310 gas chromatography system coupled with the TSQ 8000 triple quadrupole mass spectrometer (Thermo Scientific, Austin, TX, USA) followed by silylation with the BSTFA + 1% TMCS derivatization method. Biochemical parameters, including total cholesterol, HDL-C, LDL-C, triglycerides, fasting glucose, HbA1c, and Creatinine, were assessed for each participant. Trained professionals conducted anthropometric and physical examinations (which included taking blood pressure and heart rate measurements) and family history collection. Results: A total of 112 Kazakh individuals with prediabetes and 55 without prediabetes, aged 36–65 years, were included in the study. Only Alanine and valine showed a significant association with prediabetes risk among the 13 AAs analyzed. Our findings revealed an inverse relationship between Alanine and Valine and prediabetes in individuals of Kazakh ethnicity. Conclusion: A lower serum level of Alanine and Valine may serve as a predictive biomarker for prediabetes in the Kazakh population. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20754426
Volume :
14
Issue :
10
Database :
Academic Search Index
Journal :
Journal of Personalized Medicine
Publication Type :
Academic Journal
Accession number :
180527290
Full Text :
https://doi.org/10.3390/jpm14101067