基于数据挖掘的中药专利复方治疗肾病综合征的 用药规律研究.

OBJECTIVE: To analyze the medication characteristics and rules of traditional Chinese medicine patent compound in the treatment of nephrotic syndrome by using data mining technology, so as to provide reference for clinical treatment and new drug development. METHODS: Traditional Chinese medicine patent compound in the treatment of nephrotic syndrome in Announcement of Chinese Patent Publication of China National Intellectual Property Administration (http:/ / epub. cnipa. gov. cn) from Sept. 10th, 1985 to Nov. 1st, 2023 were retrieved. The drug frequency, theory of four natures, five flavors and meridian tropism, association rule analysis and systematic cluster analysis of traditional Chinese medicine patent compound that met the inclusion criteria were conducted by using the Ancient And Modern Medical Record Cloud Platform V2. 3. 7 and SPSS Statistics 26. 0 software. RESULTS: A total of 88 kinds of traditional Chinese medicine patent compound were enrolled, including 249 traditional Chinese medicines. In terms of drug frequency, in descending order, Hedysarum multijugum maxim, Atractylodes macrocephala koidz, Alisma orientale (Sam.) juz, Poria cocos (Schw.) wolf, and Rhizoma dioscoreae. In terms of four natures, five flavors and meridian tropism, the four natures were flat, the five flavors were sweet, and the meridian tropism was liver. In terms of association rules, the confidence levels from high to low were Atractylodes macrocephala koidz-Hedysarum multijugum maxim, Poria cocos (Schw.) Wolf-Hedysarum multijugum maxim, Alisma orientale (Sam.) juz-Hedysarum multijugum maxim. In terms of systematic clustering, the obtained drug combinations included Rehmanniae Radix Praeparata, Cornus Officinalis Sieb. Et Zucc, Rhizoma dioscoreae, Euryales semen, Leonuri herba, Imperatae rhizoma and Hedysarum multijugum maxim, Codonopsis Radix, and licorice. CONCLUSIONS: The treatment of nephrotic syndrome by traditional Chinese medicine patent compound focuses on spleen and kidney co-regulation, Qi, blood and water treatment, and takes strengthening the spleen and tonifying the kidney, inducing diuresis and eliminating dampness, activating blood circulation and removing blood stasis as the basic treatment, which can develop ideas and provide references for the clinical treatment of the disease and the research and development of new drugs. [ABSTRACT FROM AUTHOR]