Representing the dynamics of natural marmoset vocal behaviors in frontal cortex.

Here, we tested the respective contributions of primate premotor and prefrontal cortex to support vocal behavior. We applied a model-based generalized linear model (GLM) analysis that better accounts for the inherent variance in natural, continuous behaviors to characterize the activity of neurons throughout the frontal cortex as freely moving marmosets engaged in conversational exchanges. While analyses revealed functional clusters of neural activity related to the different processes involved in the vocal behavior, these clusters did not map to subfields of prefrontal or premotor cortex, as has been observed in more conventional task-based paradigms. Our results suggest a distributed functional organization for the myriad neural mechanisms underlying natural social interactions and have implications for our concepts of the role that frontal cortex plays in governing ethological behaviors in primates. • Neurons in marmoset monkey PFC and PMC recorded during natural conversations • GLM and PSTH were applied to quantify neural activity in continuous behavior • Model-based approach robustly outperformed more traditional analyses • Neurons in behavior-related functional clusters were distributed throughout PFC/PMC Li and colleagues applied model-based and traditional analyses to characterize single-neuron responses in the frontal cortex while marmosets engaged in their natural conversational exchanges. Results showed that the population supported nearly all facets of this ethological behavior through an anatomically distributed—but functionally modular—pattern of neural activity. [ABSTRACT FROM AUTHOR]