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Biodegradable Acid‐Responsive Nanocarrier for Enhanced Antibiotic Therapy Against Drug‐Resistant Helicobacter Pylori via Urease Inhibition.
- Source :
-
Advanced Functional Materials . Nov2024, p1. 12p. 8 Illustrations. - Publication Year :
- 2024
-
Abstract
- Metal ion‐based inhibition of urease activity is a promising strategy for treating <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infections. However, the challenges of safe delivery and reducing cytotoxicity persist. In this study, an innovative nanocarrier capable of acid‐responsive release of Ag+ and antibiotics is developed, with complete degradation after treatment. Mesoporous organosilica nanoparticle (MON) is encapsulated with hyaluronic acid (HA) to prevent drug leakage and further coated with bacterial outer membrane vesicle (OMV) from <italic>Escherichia coli</italic> Nissle 1917, creating a nanocarrier with cell‐protective capabilities. Ag+ and antibiotic clarithromycin (CLR) are incorporated into the nanocarrier to form CLR‐Ag+@MON@HA@OMV (CAMO), designed for the targeted treatment of gastric <italic>H. pylori</italic> infection. The HA encapsulation ensures acid‐responsive release of CLR and Ag+ in the stomach, preventing premature release at non‐inflammatory sites. There is a potential for Ag⁺ in CAMO to replace Ni2⁺ at the active site of urease, enhancing the bactericidal effect of CLR through urease inhibition. Furthermore, the OMV provides additional cytoprotection, mitigating cell damage and inflammation response induced by the <italic>H. pylori</italic> infection. This study introduces a safe and effective nanocarrier that eradicates <italic>H. pylori</italic> and alleviates gastric inflammation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1616301X
- Database :
- Academic Search Index
- Journal :
- Advanced Functional Materials
- Publication Type :
- Academic Journal
- Accession number :
- 180916696
- Full Text :
- https://doi.org/10.1002/adfm.202412893