Novel Emerging Mechanisms in Acetaminophen (APAP) Hepatotoxicity.

ABSTRACT Background Aims Materials & Methods Results Discussion & Conclusion Drug‐induced liver injury represents a critical public health issue, marked by unpredictable and potentially severe adverse reactions to medications, herbal products or dietary supplements.Acetaminophen is notably a leading cause of hepatotoxicity, impacting over one million individuals worldwide.Extensive research has elucidated the intricate mechanisms driving APAP‐induced liver injury, emphasising the significant roles of endoplasmic reticulum stress, oxidative stress, mitochondrial dysfunction and cell death.These insights pave the way for innovative therapeutic strategies, including the use of magnesium, bile acids, microbiota modulation and mesenchymal stem cells.This review explores into these pathological mechanisms, proposing viable therapeutic interventions for patients suffering from APAP‐induced liver injury. [ABSTRACT FROM AUTHOR]