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Design and synthesis of 3,5-disubstituted isoxazoles by Cu-mediated 1,3-dipolar cycloaddition and their in silico evaluation as potential GABAB receptor modulators.

Authors :
Martínez-Campos, Zuleyma
Palacios-Can, Francisco José
López-Cortina, Susana T.
Razo-Hernández, Rodrigo Said
Fernández-Zertuche, Mario
Source :
Tetrahedron. Dec2024, Vol. 168, pN.PAG-N.PAG. 1p.
Publication Year :
2024

Abstract

In this work, we report the synthesis of three series of 3,5-disubstituted isoxazoles (4a-d , 5a-d and 6a-d), as analogues of the clinically important drug baclofen. The isoxazole ring systems were assembled through the key copper-catalyzed 1,3-dipolar cycloaddition reaction between a nitrile oxide (generated in situ from nitro compounds) and an alkyne. An X-ray crystallography study shows that the 1,3-dipolar cycloaddition reactions proceeded with very high regioselectively, leading exclusively to the formation of the 3,5-disubstituted regio isomers. Additionally, it was possible to obtain these compounds in enantiomerically pure form using SuperQuat-type chiral auxiliary. As suggested by our QSAR analysis and docking studies, these analogues have the potential to be biologically active as GABA B receptor modulators. Finally, the absorption, distribution, properties of metabolism and excretion (ADME) of the synthesized molecules was also determined by a computational approach. From this work we obtained five molecules ((S)- 4d , (S)- 5b , (S)- 6b , (S)- 6c and (S)- 6d) as potential GABA B receptor agonists. [Display omitted] [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00404020
Volume :
168
Database :
Academic Search Index
Journal :
Tetrahedron
Publication Type :
Academic Journal
Accession number :
180930331
Full Text :
https://doi.org/10.1016/j.tet.2024.134336