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A New Amide from the Fermentation of Fusarium sp. SFS-G3 and Cytotoxic Activities.

Authors :
Yang, Min
Ma, Yue-Yu
Xiong, Rui-Feng
Dong, Miao
Hu, Qiu-Fen
Li, Yin-Ke
Source :
Chemistry of Natural Compounds. Nov2024, Vol. 60 Issue 6, p1080-1083. 4p.
Publication Year :
2024

Abstract

N-(5-((3E,5E)-10-Acetoxy-5,7,9,11-tetramethyltrideca-3,5-dien-1-yl)-2-oxotetrahydrofuran-3-yl)acetamide (1), a new amide compound, and five known ones (2–6) were isolated from the EtOH extract of the solid culture of Fusarium sp. Their structures were determined by means of extensive 1D and 2D NMR techniques, as well as comparison with literature values. Additionally, compounds 1–6 were tested for their cytotoxic activities. The results showed that compounds 2, 3, 6 exhibited cytotoxic activities against five human cancer cell lines with IC50 values ranging from 2.088 to 26.40 μM. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00093130
Volume :
60
Issue :
6
Database :
Academic Search Index
Journal :
Chemistry of Natural Compounds
Publication Type :
Academic Journal
Accession number :
180934783
Full Text :
https://doi.org/10.1007/s10600-024-04524-y