Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder.

Background Persistent cognitive deficits and functional impairments are associated with bipolar disorder (BD), even during the euthymic phase. The dysfunction of default mode network (DMN) is critical for self-referential and emotional mental processes and is implicated in BD. The current study aims to explore the balance of excitatory and inhibitory neurotransmitters, i.e. glutamate and γ -aminobutyric acid (GABA), in hubs of the DMN during the euthymic patients with BD (euBD). Method Thirty-four euBD and 55 healthy controls (HC) were recruited to the study. Using proton magnetic resonance spectroscopy (1 H-MRS), glutamate (with PRESS sequence) and GABA levels (with MEGAPRESS sequence) were measured in the medial prefrontal cortex/anterior cingulate cortex (mPFC/ACC) and the posterior cingulate gyrus (PCC). Measured concentrations of excitatory glutamate/glutamine (Glx) and inhibitory GABA were used to calculate the excitatory/inhibitory (E / I) ratio. Executive and attentional functions were respectively assessed using the Wisconsin card-sorting test and continuous performance test. Results euBD performed worse on attentional function than controls (p = 0.001). Compared to controls, euBD had higher E / I ratios in the PCC (p = 0.023), mainly driven by a higher Glx level in the PCC of euBD (p = 0.002). Only in the BD group, a marginally significant negative association between the mPFC E / I ratio (Glx/GABA) and executive function was observed (p = 0.068). Conclusions Disturbed E/I balance, particularly elevated Glx/GABA ratio in PCC is observed in euBD. The E / I balance in hubs of DMN may serve as potential biomarkers for euBD, which may also contribute to their poorer executive function. [ABSTRACT FROM AUTHOR]