Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus <italic>Talaromyces amestolkiae</italic> SCNU-F0041.

AbstractA new indigotin alkaloid, named talarindigotin A (<bold>1</bold>), along with the analogue 5H, 6H-quinindolin-11-one (<bold>2</bold>) were isolated from the mangrove endophytic fungus <italic>Talaromyces amestolkiae</italic> SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound <bold>1</bold> showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC50 values ranging from 2.08 to 4.58 μM. [ABSTRACT FROM AUTHOR]