A multi‐centre retrospective study of long‐term outcomes of spinal re‐irradiation with SABR.

Introduction: Stereotactic ablative body radiotherapy (SABR) is a highly conformal technique utilising a high dose per fraction commonly employed in the re‐treatment of spinal metastases. This study sought to determine the safety and efficacy of re‐irradiation with SABR to previously treated spinal metastases. Methods: This was a retrospective analysis of patients at three Australian centres who have undergone spinal SABR after previous spinal radiotherapy to the same or immediately adjacent vertebral level. Efficacy was determined in terms of rates of local control, while safety was characterised by rates of serious complications. Results: Thirty‐three spinal segments were evaluated from 32 patients. Median follow‐up for all patients was 2.6 years, and median overall survival was 4.3 years. Eleven of 33 (33.3%) treated spinal segments had local progression, with a local control rate at 12 months of 71.4% (95% C.I. 55.2%–92.4%). Four patients (16.7%) went on to develop cauda equina or spinal cord compression. Thirteen out of 32 patients (40.6%) experienced acute toxicity, of which 12 were grade 2 or less. Five out of 30 spinal (16.7%) segments with follow‐up imaging had a radiation‐induced vertebral compression fracture. There was one case of radiation myelitis which occurred in a patient who had mediastinal radiotherapy with a treatment field which overlapped their prior spinal radiation. Conclusion: The patients in this study experienced long median survival, durable tumour control and high rates of freedom from long‐term sequelae of treatment. These results support the use of SABR in patients who progress in the spine despite previous radiotherapy. [ABSTRACT FROM AUTHOR]