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Cardiovascular Complications and Their Association With Short- and Long-Term Outcomes in Patients With Multiple Myeloma and Lymphoma Undergoing Chimeric Antigen Receptor T-Cell Therapy.

Authors :
Itzhaki Ben Zadok, Osnat
Simitsis, Panagiotis
Jacobson, Caron
Nadeem, Omar
Frigault, Matthew J.
Raje, Noopur
Duffy, Caitlyn
Costello, Patrick
Dela Cruz, Jamie
Looka, Andrew
Nohria, Anju
Source :
Circulation. 11/26/2024, Vol. 150 Issue 22, p1815-1817. 3p.
Publication Year :
2024

Abstract

The document explores the cardiovascular complications associated with chimeric antigen receptor T-cell therapy in patients with multiple myeloma and lymphoma. The study, based on a retrospective cohort analysis, found that in-hospital cardiovascular events during CAR-T therapy were reversible and not linked to mortality, while post-discharge cardiovascular events were associated with increased mortality. The research highlights the importance of comprehensive cardiovascular assessment and management for patients undergoing CAR-T, emphasizing the need for further studies to optimize long-term outcomes. [Extracted from the article]

Details

Language :
English
ISSN :
00097322
Volume :
150
Issue :
22
Database :
Academic Search Index
Journal :
Circulation
Publication Type :
Academic Journal
Accession number :
181039726
Full Text :
https://doi.org/10.1161/CIRCULATIONAHA.124.070432