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House of CarDs: Functional insights into the transcriptional regulator CdnL.

Authors :
Smith, Erika L.
Goley, Erin D.
Source :
Molecular Microbiology. Nov2024, Vol. 122 Issue 5, p789-796. 8p.
Publication Year :
2024

Abstract

Regulation of bacterial transcription is a complex and multi‐faceted phenomenon that is critical for growth and adaptation. Proteins in the CarD_CdnL_TRCF family are widespread, often essential, regulators of transcription of genes required for growth and metabolic homeostasis. Research in the last decade has described the mechanistic and structural bases of CarD‐CdnL‐mediated regulation of transcription initiation. More recently, studies in a range of bacteria have begun to elucidate the physiological roles of CarD‐CdnL proteins as well as mechanisms by which these proteins, themselves, are regulated. A theme has emerged wherein regulation of CarD‐CdnL proteins is central to bacterial adaptation to stress and/or changing environmental conditions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0950382X
Volume :
122
Issue :
5
Database :
Academic Search Index
Journal :
Molecular Microbiology
Publication Type :
Academic Journal
Accession number :
181057761
Full Text :
https://doi.org/10.1111/mmi.15268