Effectiveness of Eryngium ilicifolium against adhesion and biofilm of carbapenem resistant Acinetobacter baumannii.

The World Health Organization has identified Acinetobacter baumannii as the most threatening multidrug-resistant pathogen, necessitating the development of new antimicrobial agents. In this study, the antibacterial, anti-adhesion, and antibiofilm activities of Eryngium ilicifolium against carbapenem resistant A. baumannii were investigated, alongside its impact on surface physicochemical properties. Among the extracts tested, only the Soxhlet diethyl ether extract exhibited effectiveness, with inhibition diameters ranging from 20.7 to 23.3 mm, and minimum inhibitory and bactericidal concentrations between 0.156 and 0.625 mg/ml. The anti-adhesion assay of this extract yielded promising results, showing inhibition percentages between 0.92% and 29.24%. However, the extract was active against only one strain of biofilm. Moreover, treatment with E. ilicifolium did not alter the hydrophobic nature of the surface. Nevertheless, the E. ilicifolium extract demonstrated significant efficacy against A. baumannii in planktonic form and could potentially serve as an effective preventive strategy against biofilm formation. [ABSTRACT FROM AUTHOR]