Comparison of Rocuronium and Succinylcholine on Intraocular Pressure during Rapid Sequence Induction of Anaesthesia -- An Observational Study.

Aim & Objective: The aim of this study was designed to compare the effect on Intraocular Pressure of Rocuronium with that of Succinylcholine during Rapid Sequence Induction of anaesthesia using Propofol and Fentanyl. Methodology: This was a sequential controlled study. The study was conducted at Apollo Institute of Medical Sciences & Research, Hyderabad, Telangana. Patients were allocated sequentially to one of two groups (n20 in each group) to receive Succinylcholine (group S) and Rocuronium (group R). All patients were medicated with Tab Alprazolam 0.5 mg orally night before surgery. Preoxygenation was done for 3 min, Anaesthesia was induced with Inj Fentanyl 2 mcg/kg and a sleep dose of Propofol given at a rate of 100 mg /min until loss of verbal response. Results: There was no significant difference between groups in Age, Sex, Weight, Propofol dose, Baseline IOP, Baseline MAP or Baseline HR. The difference in the changes in IOP between the Succinylcholine and Rocuronium groups was highly significant (P=0.001). Conclusion: To conclude Rocuronium bromide in a dose of 1 mg/kg Provides Good to Excellent intubating conditions comparable to that of Succinylcholine. It is a suitable agent for tracheal intubation in patients undergoing elective and emergency ophthalmic surgery where raise in intraocular pressure is undesirable. [ABSTRACT FROM AUTHOR]