Bioinspired black phosphorus delivers histone deacetylase inhibitor-induced synergistic therapy for lung cancer.

The bioinspired black phosphorus was constructed to deliver the histone deacetylase inhibitor (HDACi) and termed as MBS. MBS showed excellent surface properties and acted as a multifunctional platform based on the cell membrane coating structure, which showed great potential in the delivery of a broad spectrum of HDACi and exhibited synergistic therapy by photothermal effect and chemotherapy. [Display omitted] Lung cancer remains one of the most fatal cancers worldwide, with a high incidence of metastasis and a low 5-year survival rate. Histone deacetylase inhibitors (HDACis) have shown significant potential in lung cancer treatment, but their clinical use is often hindered by poor water solubility, rapid clearance, and systemic toxicity. In this study, we developed a novel therapeutic strategy by camouflaging black phosphorus (BP) with M1 macrophage membranes (MB) and loaded HDACi suberoylanilide hydroxamic acid (SAHA) onto the camouflaged black phosphorus (MB) for targeted lung cancer therapy. The M1 membrane coating enhanced the specificity of the SAHA-loaded black phosphorus toward lung cancer cells. Black phosphorus not only served as a carrier for HDACis but also facilitated photothermal therapy (PTT) through its photothermal conversion capabilities, establishing a highly efficient therapeutic platform. MBS demonstrated strong antitumor activity with minimal systemic toxicity. This multifunctional platform, inspired by biological systems, shows great promise for delivering a wide range of HDACis and offers synergistic therapeutic potential through the combination of photothermal therapy and chemotherapy. [ABSTRACT FROM AUTHOR]