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Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Aug2005, Vol. 15 Issue 15, p3573-3575. 3p. - Publication Year :
- 2005
-
Abstract
- Abstract: (R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA2. The (R)-4 and (S)-4 exhibited Lp-PLA2 inhibitory activities with IC50 values of 45.0 and 52.0μM, respectively. [Copyright &y& Elsevier]
- Subjects :
- *FATTY acids
*GLYCERYL ethers
*ACETATES
*EXTRACTS
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 18126423
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.05.056