The Nocturnal Nexus: A Systematic Review of the Association Between Night-time Asthma and GERD Incidence.

Background: The association between nocturnal Asthma and gastroesophageal reflux disease (GERD) has been widely researched, yet its complexities remain only partially understood. This systematic review aims to elucidate the connection between night-time asthma and the incidence of GERD, with a focus on nocturnal GERD's impact on respiratory function. Methods: Adhering to PRISMA guidelines, a comprehensive search of eight databases- PubMed, EMBASE, Cochrane Library, Web of Science, Scopus, PsycINFO, CINAHL, and Google Scholar was performed to collect studies examining the link between nocturnal Asthma and GERD. Selection criteria were established a priori, and data from relevant studies were extracted and assessed for methodological quality. Results: Our review synthesized data from eleven studies that consistently showed a link between nocturnal GERD and Asthma. Night-time GERD episodes were found to correlate with increased respiratory load and a higher risk of developing respiratory symptoms and Asthma. While all studies supported the detrimental impact of nocturnal GERD on respiratory health, they varied regarding specific respiratory outcomes and the timing of symptom manifestation. Evidence pointed to both immediate and delayed physiological responses to GERD, complicating the asthma management process. Conclusion: The systematic review confirms a significant association between nocturnal GERD and respiratory health issues, including increased respiratory load and the development of Asthma and related symptoms. These findings highlight the importance of considering nocturnal GERD in the management of respiratory conditions, particularly Asthma, and suggest a need for tailored treatment strategies to address this complex interplay. [ABSTRACT FROM AUTHOR]