Adverse Outcomes After Tunneled Dialysis Catheter–Related Bloodstream Infections—Too Dark at the End of This Tunnel?

ABSTRACT Background Aims and Objectives Results Conclusion Trial Registration Tunneled dialysis catheters (TDCs) are preferred over temporary noncuffed catheters for access in patients on maintenance hemodialysis. The removal of TDC after catheter‐related blood stream infections (CRBSIs) is often not practiced even when indicated, and the adverse outcomes after such salvage are presently unclear.The study aimed to evaluate adverse outcomes after the first episode of definite or probable CRBSI. The composite adverse outcome was recorded as the presence of at least one of three adverse outcomes—death in the index hospital admission, occurrence of recurrent bacteremia, and death within 3 months.During the study period, the TDC CRBSI incidence rate was 6.9/1000 catheter days. Of the 110 study participants, majority were male (63%), with a median age of 35 years, belonging to rural (56%) and agrarian (39%) communities, and 66% were getting dialyzed at stand‐alone dialysis units. Gram‐negative infections predominated (64%), with 37% of isolates showing resistance to carbapenems. Catheter salvage was practiced in 80%, and immediate catheter removal was done only in the sickest of patients (in seven of eight with in‐hospital mortality). Predictors of composite adverse outcomes included sites other than right internal jugular vein (OR 3.6) and resistance to β lactam‐β lactamase inhibitors (OR 16.2). At a median follow‐up of 7 months, all survivors at 3 months were alive and 46% had recurrent TDC CRBSIs.Up to one‐half of patients with end‐stage kidney disease experienced composite adverse outcomes after the first episode of TDC CRBSI, with infection‐related 3‐month mortality of 15%.Clinical trial number: CTRI/2023/10/058556 [ABSTRACT FROM AUTHOR]