In Reply.

The article "In Reply" from Obstetrics & Gynecology discusses the Clinical Expert Series on lasers and gynecology, focusing on a 2022 review by Mortenson et al that included a study on CO2 laser treatment for lichen sclerosis. The study found no significant difference in histopathologic studies between sham-laser and CO2 laser treatments. The authors also address the issue of using histologic changes as the primary outcome for vulvar lichen sclerosis, emphasizing that it is a clinical diagnosis and biopsy may not be necessary unless there are specific concerns. [Extracted from the article]