铁死亡抑制剂在缺血性脑卒中中的作用.

Ferroptosis is a new type of programmed cell death characterized by iron overload and lipid peroxidation, which is different from other cell death patterns, such as apoptosis, necrosis and autophagy, etc. In recent years, ferroptosis has attracted wide attention in nervous system diseases, such as ischemic stroke (IS), Alzheimer’s disease, Parkinson’s disease and Huntington’s disease, etc. Studies have found that ferroptosis participates in and aggravates the pathological process of IS, and ferroptosis inhibitors can effectively improve the prognosis of IS. Therefore, this article mainly reviews the pathogenesis of ferroptosis in IS and the application of ferroptosis inhibitors in IS, in order to provide a new potential intervention target for the prevention and treatment of IS. [ABSTRACT FROM AUTHOR]