Back to Search
Start Over
Hypervalent Iodine-Mediated Synthesis of Steroidal 5/5-Spiroiminals.
Hypervalent Iodine-Mediated Synthesis of Steroidal 5/5-Spiroiminals.
- Source :
-
Molecules . Dec2024, Vol. 29 Issue 23, p5812. 11p. - Publication Year :
- 2024
-
Abstract
- The hypervalent iodine-mediated formation of steroidal 5/5-spiroiminals and 5/5-spiroaminals from steroidal amines is presented. Under the influence of excess PhI(OAc)2 and iodine in acetonitrile at 0 °C, steroidal amines smoothly underwent cyclization to give a mixture of 5/5-spiroiminals and 5/5-spiroaminals. This reaction represents the first example of a C-H-activation-mediated formation of a spiroiminal. Presumably, the formation of 5/5-spiroiminals occurs through aminyl radical-mediated cyclization followed by amine-to-imine oxidation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACETONITRILE
*IODINE
*AMINES
*OXIDATION
*MIXTURES
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 29
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 181660885
- Full Text :
- https://doi.org/10.3390/molecules29235812