Effectiveness of radiotherapy in patients with primary invasive vaginal carcinoma.

Introduction: The aim of the study was to present an institutional experience in radiation therapy of primary invasive vaginal carcinoma (PIVC) patients treated in the Krakow Branch of Centre of Oncology, with special regard to treatment effectiveness and failure causes. Materials and Methods: Between February 1967 and January 2007,162 PIVC patients were treated with radical radiotherapy in the Krakow Branch of Centre of Oncology, Maria Sklodowska-Curie Memorial Institute. Twenty-seven (16.7%) patients in Stage 1° were treated with intracavitary brachytherapy alone; for 127 (78.4%) patients in Stage 1° - IV0 intracavitary brachytherapy was combined with external radiation therapy; and eight (4.9%) patients in Stage IVA0 were given only external radiotherapy. Results: In the investigated group of 162 patients, five-year disease-free survival was observed in 46.3% of the cases. Patient age and FIGO Stage of neoplastic disease were independent prognostic factors. Five-year disease-free survival was observed in 64.9% of the patients < 60 years of age and only in 30.7% > 60 years of age; and in 62.3% of PIVC patients in Stages I and II0 as compared to 19.7% of Stages III0 and IV0 cases. Among 78 patients who died of PIVC, in 60 (76.9%) cases the cause of death was locoregional failure; in six (7.7%), locoregional failure and distant metastasis; and in 12 (15.4%), distant metastasis. Conclusions: Radiotherapy is effective treatment for PIVC patients. Age below 60 years and non-advanced neoplastic disease were independent favourable prognostic factors in the investigated group of patients. The primary cause of treatment failure was failure to achieve locoregional disease control. [ABSTRACT FROM AUTHOR]