Can We Noninvasively Rule Out Acute Rejection? External Validation of a Urinary Chemokine-Based Model.

The article discusses the validation of a model for noninvasive diagnosis of acute rejection in kidney transplant recipients using urinary chemokines CXCL9 and CXCL10. The study aimed to validate the model in an independent cohort of patients and found that the model slightly overestimated the risk of acute rejection, particularly in patients at higher risk. Despite this, the model showed good discriminatory capacity and may be useful for identifying patients at low risk of acute rejection who can safely avoid biopsies. The findings support the utility of this model in clinical decision-making for kidney transplant recipients. [Extracted from the article]