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Recent developments in the photoredox catalyzed Minisci-type reactions under continuous flow.

Authors :
Pillitteri, Serena
Van der Eycken, Erik V.
Sharma, Upendra K.
Source :
Chemical Communications. 1/4/2025, Vol. 61 Issue 1, p13-22. 10p.
Publication Year :
2025

Abstract

The Minisci reaction constitutes a straightforward and convenient strategy to achieve the direct C–H functionalization of heterocyclic molecules. This radical-based reaction platform has received increasing attention due to the predictability of its outcome according to the nature of the radicals and heterocycles involved. Considering the importance of these heterocyclic scaffolds in the development and production of drug molecules, it is inevitable that scaling up this reaction manifold is of utmost importance. This review will present recent strategies to achieve the goal, which mostly involve implementing the reaction conditions under continuous flow. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13597345
Volume :
61
Issue :
1
Database :
Academic Search Index
Journal :
Chemical Communications
Publication Type :
Academic Journal
Accession number :
181713769
Full Text :
https://doi.org/10.1039/d4cc04801f