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The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders
- Source :
-
Journal of Dermatological Science . Aug2005, Vol. 39 Issue 2, p71-80. 10p. - Publication Year :
- 2005
-
Abstract
- Summary: Pattern-recognition receptors are a first line of defense against invading pathogens. Recent advances in the understanding of innate immunity have revealed a novel family of cytosolic pattern-recognition receptors called Nods, which contain an amino-terminal effector-binding domain, a centrally located nucleotide-binding oligomerization domain (NOD) and a carboxy-terminal ligand recognition domain. Hereditary mutations of Nods have been reported in patients with certain inflammatory diseases; for example, Nod2 mutations are associated with the inflammatory granulomatous disorders, Crohn''s disease and Blau syndrome. Missense mutations of Nod2 are also associated with early-onset sarcoidosis, a rare but sporadic disease. Because Nod2 is predominantly expressed in monocytes and recognizes a component of bacterial peptidoglycan, analysis of its function may help in understanding the role of the immune system in granuloma formation. [Copyright &y& Elsevier]
- Subjects :
- *PATHOGENIC microorganisms
*LEUCOCYTES
*IMMUNE system
*SARCOIDOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 09231811
- Volume :
- 39
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Dermatological Science
- Publication Type :
- Academic Journal
- Accession number :
- 18179806
- Full Text :
- https://doi.org/10.1016/j.jdermsci.2005.04.001