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The Role and Applied Value of Mitochondria in Glioma‐Related Research.

Authors :
Chen, Liwen
Zhang, Hui
Shang, Chao
Hong, Yang
Source :
CNS Neuroscience & Therapeutics. Dec2024, Vol. 30 Issue 12, p1-18. 18p.
Publication Year :
2024

Abstract

Mitochondria, known as the "energy factory" of cells, are essential organelles with a double membrane structure and genetic material found in most eukaryotic cells. They play a crucial role in tumorigenesis and development, with alterations in mitochondrial structure and function in tumor cells leading to characteristics such as rapid proliferation, invasion, and drug resistance. Glioma, the most common brain tumor with a high recurrence rate and limited treatment options, has been linked to changes in mitochondrial structure and function. This review focuses on the bioenergetics, dynamics, metastasis, and autophagy of mitochondria in relation to glioma proliferation, as well as the potential use of mitochondria‐targeting drugs in glioma treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17555930
Volume :
30
Issue :
12
Database :
Academic Search Index
Journal :
CNS Neuroscience & Therapeutics
Publication Type :
Academic Journal
Accession number :
181967377
Full Text :
https://doi.org/10.1111/cns.70121