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2-Aminoquinazoline inhibitors of cyclin-dependent kinases
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Sep2005, Vol. 15 Issue 17, p3881-3885. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds that inhibit Cdk4 selectively are targeted for treating cancer. Appropriate substitution of 2-aminoquinazolines is demonstrated to produce high levels of selectivity for Cdk4 versus closely related serine-threonine kinases. [Copyright &y& Elsevier]
- Subjects :
- *CYCLIN-dependent kinases
*PROTEIN kinases
*PHOSPHOTRANSFERASES
*TRANSFERASES
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 18221891
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.05.131