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Animal models of multiple system atrophy
- Source :
-
Trends in Neurosciences . Sep2005, Vol. 28 Issue 9, p501-506. 6p. - Publication Year :
- 2005
-
Abstract
- Multiple system atrophy (MSA) is a fatal neurodegenerative disorder presenting with autonomic failure and motor impairment, primarily comprising l-dopa-resistant parkinsonism but occasionally involving cerebellar ataxia. These features result from progressive multisystem neuronal loss that is associated with oligodendroglial α-synuclein inclusions. The growing number of animal models for MSA reflects the search for a preclinical test-bed for elucidating MSA pathogenesis and for developing novel therapeutic interventions. Here, the currently available MSA animal models will be reviewed and leads for future research will be identified. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01662236
- Volume :
- 28
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Trends in Neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 18233074
- Full Text :
- https://doi.org/10.1016/j.tins.2005.07.002